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Hippenmeyer Group

Genetic Dissection of Cerebral Cortex Development

The human cerebral cortex, the seat of our cognitive abilities, is composed of an enormous number and diversity of neurons and glia cells. How the cortex arises from neural stem cells is an unsolved but fundamental question in neuroscience. In the pursuit of mechanistic insights, the Hippenmeyer group genetically dissects corticogenesis at unprecedented single cell resolution using the unique MADM (Mosaic Analysis with Double Markers) technology.

The Hippenmeyer group’s current objectives are 1) to establish a definitive quantitative and mechanistic model of cortical neural stem cell lineage progression; 2) to dissect the cellular and molecular mechanisms generating cell-type diversity; 3) to determine the role of genomic imprinting, an epigenetic phenomenon, in cortex development. In a broader context, the group’s research has the ultimate goal to advance the general understanding of brain function and why human brain development is so sensitive to disruption of particular signaling pathways in pathological neurodevelopmental diseases and psychiatric disorders

On this site:


Image of Raquel Casado Polanco

Raquel Casado Polanco

PhD Student

Image of Giselle Cheung

Giselle Cheung


Image of Sophie Gobeil

Sophie Gobeil

PhD Student

Image of Osvaldo Miranda Romero

Osvaldo Miranda Romero

PhD Student

Image of Florian Pauler

Florian Pauler

Research Technician

Image of Fabrizia Pipicelli

Fabrizia Pipicelli


Image of Melissa Stouffer

Melissa Stouffer


Image of Carmen Streicher

Carmen Streicher

Research Technician

+43 2243 9000 7434

Image of Ana Villalba Requena

Ana Villalba Requena


Current Projects

Determine neuronal lineages by clonal analysis | Mechanisms generating cell-type diversity | Probing genomic imprinting in cortex development


Knaus L, Basilico B, Malzl D, Gerykova Bujalkova M, Smogavec M, Schwarz LA, Gorkiewicz S, Amberg N, Pauler F, Knittl-Frank C, Tassinari M, Maulide N, Rülicke T, Menche J, Hippenmeyer S, Novarino G. 2023. Large neutral amino acid levels tune perinatal neuronal excitability and survival. Cell. 186(9), 1950–1967.e25. View

Hippenmeyer S. 2023. Principles of neural stem cell lineage progression: Insights from developing cerebral cortex. Current Opinion in Neurobiology. 79(4), 102695. View

Ladle DR, Hippenmeyer S. 2023. Loss of ETV1/ER81 in motor neurons leads to reduced monosynaptic inputs from proprioceptive sensory neurons. Journal of Neurophysiology. 129(3), 501–512. View

Villalba Requena A, Hippenmeyer S. 2023. Going back in time with TEMPO. Neuron. 111(3), 291–293. View

Amberg N, Pauler F, Streicher C, Hippenmeyer S. 2022. Tissue-wide genetic and cellular landscape shapes the execution of sequential PRC2 functions in neural stem cell lineage progression. Science Advances. 8(44), abq1263. View

View All Publications

ReX-Link: Simon Hippenmeyer


since 2019 Professor, Institute of Science and Technology Austria (ISTA)
2012 – 2019 Assistant Professor, Institute of Science and Technology Austria (ISTA)
2011 – 2012 Research Associate, Stanford University, Palo Alto, USA
2006 – 2011 Postdoctoral Fellow, Stanford University, Palo Alto, USA
2004 – 2006 Postdoctoral Associate, University of Basel and Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
2004 PhD, University of Basel, Switzerland

Selected Distinctions

2016 ERC Consolidator Grant
2014 HFSP Program Grant
2013 Marie Curie Career Integration Grant
2009 – 2011 Fellowship for Advanced Researchers, Swiss National Science Foundation, Bern, Switzerland
2007 – 2009 HFSP Long-term Fellowship
2006 EMBO Long-term Fellowship
2005 Natural Sciences Faculty Prize for the best PhD thesis of the year
2004, University of Basel, Switzerland
2005 Edmond H. Fischer Prize

Additional Information

Download CV
Open Hippenmeyer group website

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