Schur Group
Structural Biology of Cell Migration and Viral Infection
The Schur group aims to understand the structural and functional principles that control cell migration. In other projects the group tries to elucidate evolutionary conserved assembly and maturation mechanisms in retroviruses. To this end they use and develop advanced cryo-electron microscopy and image processing methods to study the structure and function of protein complexes in situ.
In the field of cell migration, the group focuses on the actin cytoskeleton, the key player allowing cells to move. Here they aim to obtain an understanding how cells dynamically and productively adapt the actin cytoskeleton to move in defined directions, by varying the activity of a large number of regulatory proteins.
In the field of virology, the group studies the structure of pleomorphic viruses by improving the versatility of cryo-EM data acquisition and the image processing methods. Specifically, the group is interested in the conservation and diversity of retroviral capsid assemblies, and why retroviruses developed a dependence on charge-compensatory molecules for assembly and maturation.
Group Leader
Administrative Support
On this site:
Team
Current Projects
Cellular structural biology of the actin cytoskeleton and cell migration | Structural Conservation and Diversity of Retroviral Capsid | Cryo-electron tomography and image processing method development
Publications
Dimchev GA, Amiri B, Fäßler F, Falcke M, Schur FK. 2023. Computational toolbox for ultrastructural quantitative analysis of filament networks in cryo-ET data, Institute of Science and Technology Austria, 10.15479/AT:ISTA:14502. View
Koch J, Xin Q, Obr M, Schäfer A, Rolfs N, Anagho HA, Kudulyte A, Woltereck L, Kummer S, Campos J, Uckeley ZM, Bell-Sakyi L, Kräusslich HG, Schur FK, Acuna C, Lozach PY. 2023. The phenuivirus Toscana virus makes an atypical use of vacuolar acidity to enter host cells. PLoS Pathogens. 19(8), e1011562. View
Fäßler F, Javoor M, Schur FK. 2023. Deciphering the molecular mechanisms of actin cytoskeleton regulation in cell migration using cryo-EM. Biochemical Society Transactions. 51(1), 87–99. View
Fäßler F, Javoor M, Datler J, Döring H, Hofer F, Dimchev GA, Hodirnau V-V, Faix J, Rottner K, Schur FK. 2023. ArpC5 isoforms regulate Arp2/3 complex–dependent protrusion through differential Ena/VASP positioning. Science Advances. 9(3), add6495. View
Nicolas WJ, Fäßler F, Dutka P, Schur FK, Jensen G, Meyerowitz E. 2022. Cryo-electron tomography of the onion cell wall shows bimodally oriented cellulose fibers and reticulated homogalacturonan networks. Current Biology. 32(11), P2375-2389. View
ReX-Link: Florian Schur
Career
since 2017 Assistant Professor, Institute of Science and Technology Austria (ISTA)
2016 – 2017 Postdoc, European Molecular Biology Laboratory, Heidelberg, Germany
2016 PhD, European Molecular Biology Laboratory, Heidelberg and University of Heidelberg, Germany
Selected Distinctions
2022 ERC Starting Grant
2021 FEBS Excellence Award
2021 EMBO Young Investigator
2021 ChanZuckerberg Initiative Visual proteomics grant
2020 FWF Standalone research grant
2018 FWF Standalone research grant
2016 Journal of Structural Biology, Paper of the Year Award
