Structural Biology of Cell Migration and Viral Infection
The Schur group aims to understand the structural and functional principles that control cell migration. In other projects the group tries to elucidate evolutionary conserved assembly and maturation mechanisms in retroviruses. To this end they use and develop advanced cryo-electron microscopy and image processing methods to study the structure and function of protein complexes in situ.
In the field of cell migration, the group focuses on the actin cytoskeleton, the key player allowing cells to move. Here they aim to obtain an understanding how cells dynamically and productively adapt the actin cytoskeleton to move in defined directions, by varying the activity of a large number of regulatory proteins.
In the field of virology, the group studies the structure of pleomorphic viruses by improving the versatility of cryo-EM data acquisition and the image processing methods. Specifically, the group is interested in the conservation and diversity of retroviral capsid assemblies, and why retroviruses developed a dependence on charge-compensatory molecules for assembly and maturation.
On this site:
+43 2243 9000 0
Cellular structural biology of the actin cytoskeleton and cell migration | Structural Conservation and Diversity of Retroviral Capsid | Cryo-electron tomography and image processing method development
Nicolas WJ, Fäßler F, Dutka P, Schur FK, Jensen G, Meyerowitz E. 2022. Cryo-electron tomography of the onion cell wall shows bimodally oriented cellulose fibers and reticulated homogalacturonan networks. Current Biology. 32(11), P2375-2389. View
Obr M, Hagen WJH, Dick RA, Yu L, Kotecha A, Schur FK. 2022. Exploring high-resolution cryo-ET and subtomogram averaging capabilities of contemporary DEDs. Journal of Structural Biology. 214(2), 107852. View
Windhaber S, Xin Q, Uckeley ZM, Koch J, Obr M, Garnier C, Luengo-Guyonnot C, Duboeuf M, Schur FK, Lozach P-Y. 2022. The Orthobunyavirus Germiston enters host cells from late endosomes. Journal of Virology. 96(5), e02146-21. View
Dimchev GA, Amiri B, Fäßler F, Falcke M, Schur FK. 2021. Computational toolbox for ultrastructural quantitative analysis of filament networks in cryo-ET data. Journal of Structural Biology. 213(4), 107808. View
Obr M, Schur FK, Dick RA. 2021. A structural perspective of the role of IP6 in immature and mature retroviral assembly. Viruses. 13(9), 1853. View
ReX-Link: Florian Schur
since 2017 Assistant Professor, Institute of Science and Technology Austria (ISTA)
2016 – 2017 Postdoc, European Molecular Biology Laboratory, Heidelberg, Germany
2016 PhD, European Molecular Biology Laboratory, Heidelberg and University of Heidelberg, Germany
2022 ERC Starting Grant
2021 FEBS Excellence Award
2021 EMBO Young Investigator
2021 ChanZuckerberg Initiative Visual proteomics grant
2020 FWF Standalone research grant
2018 FWF Standalone research grant
2016 Journal of Structural Biology, Paper of the Year Award